Elevated Serum Levels of IL-21 in Kawasaki Disease

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Elevated Serum Levels of IL-21 in Kawasaki Disease

PURPOSE The serum level of immunoglobulin (Ig)E has been reported to be elevated in patients with Kawasaki disease (KD). We investigated whether interleukin (IL)-21, rather than IL-4, could be related to elevated serum levels of IgE in KD. METHODS Sera from 48 patients with KD and 12 controls with high fever were collected to determine the level of IgE using an immunoassay system and the leve...

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BACKGROUND Interleukin (IL)15 is a novel cytokine that induces T cell proliferation, B cell maturation, natural killer cell cytotoxicity, and may have a pivotal role in the pathogenesis of inflammatory disease, acting upstream from tumour necrosis factor alpha (TNFalpha). Kawasaki disease (KD) is an inflammatory disease, in which serum levels of inflammatory cytokines such as TNFalpha and IL6 a...

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ژورنال

عنوان ژورنال: Allergy, Asthma & Immunology Research

سال: 2012

ISSN: 2092-7355,2092-7363

DOI: 10.4168/aair.2012.4.6.351